Li S, Zhu J, Wu L, Peng L, Luo Y, Zhao Y, et al. Epidemiology of homocysteine as a risk factor in diabetes. Seminars in vascular medicine 2002: Copyright© 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.īecker A, Smulders Y, Van Guldener C, Stehouwer C. Diabetes mellitus and hyperhomocysteinemia. Characterization of the stress-inducing effects of homocysteine. Outinen PA, Patricia C, SARGE KD, MAEDA N, HIRSH J, RIBAU J, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. What do we know about homocysteine and exercise? A review from the literature.įrosst P, Blom H, Milos R, Goyette P, Sheppard CA, Matthews R, et al. Maroto-Sánchez B, Lopez-Torres O, Palacios G, González-Gross M. In general, this study showed that the presence of C677T polymorphism in the MTHFR gene has no effect on the incidence of MS. As well, the results showed no statistically significant correlation between polymorphism genotypes of the MTHFR gene and MS (P<0.05). C (95% confidence interval : 1.626-0.715), 1.157 for the allele model of CC vs. The odds ratio was estimated to be 1.078 for the allele model of T vs. After extracting the data from seven articles, the total number of subjects was 1280 in the patient group and 1374 in the control group. Data was analyzed using Comprehensive Meta-Analysis version 2.2.064 software. The articles were studied based on keywords including MTHFR, mutation, variant, and polymorphism in combination with MS. We used search engines and databases such as Science Direct, Google Scholar, Embase, Cochrane Library, and PubMed to identify eligible studies up to 2018. The aim of this systematic review and meta-analysis was to study the relationship between MTHFR gene polymorphism and metabolic syndrome (MS). Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role as a methyl-group donor in demethylation of homocysteine. Non-Communicable Disease Center, Fasa University of Medical Sciences, Fasa, Iran Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, IranĢ. Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iranġ. Non-Communicable Disease Research Center, Fasa University of Medical Sciences, Fasa, Iran Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran Department of Laboratory Sciences, Faculty of Paramedicine, Mazandaran University of Medical Sciences, Sari, Iran
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